They all came back negative ! To help you get started read our. I will follow up with some testing for myself per the counselors advice but am so thankful for my outcome and sincerely hope that everyone else going through it finds their happy ending. I have a happy healthy 8 month old. This time around it came back and said suspected maternal mosaciasm and completely inconclusive. Thank you for replying. Reasons behind an inconclusive prenatal paternity test. Lastly, the information in this post is intended for you to be able to read up on what may be happening, have these studies available to you so you can better discuss this situation and your options with your maternal fetal medicine doctor and a GOOD genetic counselor. It's reassuring that things look okay on a 16 week ultrasound but sometimes things don't show up until 20 week ultrasound. Reason being: these tests utilize actual DNA and not soft markers. This is the route I took with my son (now 4.5) so I'm familiar with it. Science has produced many safe, medically sound, and accurate methods to determine the sex of a fetus during pregnancy. I got the results yesterday and another inconclusive. Identifying the genetic basis of familial disorders that affect children and adults. In some cases, a test result might not give any useful information. Thank you, I am hoping it's just a silly lab error. versttning med sammanhang av "invasiva tester inte kan" i svenska-engelska frn Reverso Context: nr invasiva tester inte kan gras eller Create an account or log in to participate. Please also place a flair on your username which can be done by going to the right side of the sub -- community options -- and update username flair. Nipt test inconclusive twice - Page 2: Has anyone had the test come out inconclusive twice? I also have been reading a lot on this (as I am sure you have too) low fetal fraction doesnt necessarily mean anything is wrong and we didnt fail the test, the test failed us! Thanks! 2) NIPT tests are more accurate and test for MORE genetic disorders (they also tell you sex, if you want to know). Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. But yes anyway, I'm sure it will all be fine. Please thank your mum for me. It's a screening test offered during pregnancy to see if the fetus is at risk for having a chromosomal disorder like Down syndrome (trisomy 21), trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). Someone please help calm my nerves! Here is a list of the most common questions we are asked. It was determined that most likely I was missing partial or all X chromosomes (monosomy x, also know as Turner syndrome) but we couldnt be 100% it wasnt the baby without doing an amnio and a karyotype blood test on me. With my first daughter there was an ECF as well that resolved itself. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Analysis of genes involved in drug metabolism and hypersensitivity, allowing clinicians to prescribe with confidence. There are certain tests which require very specific information from the requesting doctor to enable an accurate interpretation. The information on this website is provided for your general information and is not a substitute for the specific advice of your treating doctor. Mine is also only 1mm over so I'm sure it will be find it's just the not knowing! Sorry youve gone through this stress xx. I have a very minor under active thyroid that I maintain with a low dose of medication. Sorry to bump an old post, but I am wondering if any of you ladies had the option to do both NIPT (Harmony) and NT? Ive done nipt through generations and Harmony both reputable brands and they would never give results with that low of a fraction, as it could come from contamination from say, the person drawing the bloods or the one analysing touching the tube to read results. In medicine, a laboratory test that checks for certain genes, proteins, or other molecules in a sample of tissue, blood, or other body fluid. Had my redraw at 13+2, and results have come back the same . Update: my redraw came back low risk for everything! Unfortunately your NIPT result wont be available today as anticipated due to a technical issue with the assay. Your story is wonderful. It can be caused by being plus sized.something about the blood concentration being different or something. Did you opt for an amnio? What was your BMI and how many weeks/days did you have your NIPT done that showed results? TX: IUI #1 with Follistim. I will tag your post with POST FLAIR on which you can click and find similar posts about your result. NIPT Test Results Inconclusive! 20052023 BabyCenter, LLC, a Ziff Davis company. But I wish you all the best! They are up to 99% accurate for chromosomal abnormalities. Negative impact on family and personal relationships. Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. you will see them all over the place here. It can be caused by being plus sizedsomething about the blood concentration being different or something. It's so hard to be on pins and needles, I find it worst when I'm trying to fall asleep. Contact us today to learn more about everything that we can do for you. What to Expect has thousands of open discussions happening each day. PlayRightParent 11.6K subscribers Join Subscribe 127 Share 61K views 4 years ago #nipt #nipttest #genetictesting Like our videos? the most helpful and trustworthy pregnancy and parenting information. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. NIPT differs from conventional prenatal screening methods in two important ways. They have offered me a redraw. and mine came back at 3.7% and couldn't be read. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Please guide us. It can come with its own set of risks. Seems unfair to leave you in limbo not knowing. Thus, if you received no result during your non-invasive prenatal paternity test, then it might be best to check if any of these 3 factors might be in play. . NIPT is commonly used for chromosomal disorders that are caused by the presence of an extra (triploidy) or missing copy (aneuploidy) of a chromosome. There was another post on here about the same issue. They said since they dont know which of my cells are missing the X because they only take a sample size, its hard to pinpoint what is impacted or not. Another blood draw at a later week of pregnancy may have more fetal DNA so that we can get a high quality . They could well be inaccurate- most companies require at least 3%. However my 12 weeks nt scan and efts blood test both came back normal/ low risk for down syndrome at 1/10000. She actually specifically said that it didn't mean anything, bad or good. Thank you for sharing your story as mine is very similar with yours. Our baby showed up high risk for Turner syndrome and its quite the roller coaster ride. Has anyone had their results come back inconclusive? Just waiting for the office to call back to rebook. The #1 app for tracking pregnancy and baby growth. I wouldn't necessarily do the amnio for that if the baby is otherwise healthy. Wanted to share my NIPT experience to help anyone else who got inconclusive results.I first took my NIPT test at 10 weeks on Sept. 30. I am going to get a level 2 ultrasound before opting to a amino because like my doctor said I'm not even considered a high risk pregnancy! But how often do these tests fail to provide results, and what might such a result mean? I have the 2nd set of bloodwork next Friday and I'm praying for good results. Negative impact on family and personal relationships. I freaked out because Im only 30 with no history of dawn in the family and after I did my ultrasound the results came back with low risk for everything. It has relieved some of my anxieties. Learn more about. Just got this email from the lab doing my test!!! However, if the problem still persists, then your obstetrician might suggest alternative methods such as screening or more invasive procedures, which although accurate, carry a risk of miscarriage. She stated she was going to try a different blood test as there are a few different brands, so maybe ask your doctor about that? Please whitelist our site to get all the best deals and offers from our partners. I think in my case, my first test must have been borderline. Diagnostic fetal chromosome analysis should be offered after abnormal NIPT or in the presence of cystic hygromas despite normal NIPT. Level 17, Grosvenor Place, 225 George Street, Sydney, NSW 2000. This educational content is not medical or diagnostic advice. That means whatever caused no result the first time is still interfering with the test. why is my nipt test inconclusive. I will likely comment as well as other people in the subreddit who have had similar experiences. Keep us posted! That OB needs further education about NIPT positives and how to present such information as well as knowledge of the Positive Predictive Value of NIPT based on age. The NIPT shows that I am high risk for Turner Syndrome with my baby girl. Although I do have a very high BMI and am aware that this can cause inconclusive NIPT results too. I am definitely going to try to stay away from google. Makes me worried about why they can't pick up enough fetal DNA. unfortunately, I called the company and they won't give me any information! Easy to overthink (I sure did) and assume the worst - feels like Sod's law at the . Sources from your great-grandmother to the internet offer tales about how you tell the sex of your baby. It could either actually be me (and could it be passed down? if i have another baby in the future, not sure if I will do the NIPT again lol. I'm glad it went well for you in the end, and seeing the baby in 3D sounds reassuring and nice!! The Harmony and other cell-free DNA tests utilize fetal DNA so they are more accurate. These assays provide information that is not available from histological examination, and can help guide diagnosis, therapy, and monitoring of disease. As PP said, inconclusive just means they couldnt get an accurate measurement. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. I've read online it could happen to plus size moms? All rights reserved. I was given the option to re-test (tomorrow) in hopes of results coming back conclusive. Ive just asked my mum who works in pathology and - while this is definitely not to be taken over what your doc will explain, it could be a potential reason - her experience is that the sample hasnt been delivered to the lab within a reasonable time for testing. 1 DNA is usually located within cells. Just wondering if anyone has been through something similar :( thanks. I'm sorry to hear that! If you have been incorrectly told that the accuracy of your result is 99% without a proper Predictive Value calculation please report this somewhere as this actually leads to wrongful terminations of pregnancies in that office. Learn more about, Twins & Multiples: Your Tentative Time Table. Apparently you are able to conceive, so maybe being mosaic is not that bad after all? Non-invasive prenatal testing, commonly known as NIPT, is a way to test a fetus for the presence of certain chromosomal abnormalitiesparticularly Down syndromewithout the risks associated with more invasive procedures like amniocenteses.The necessary information can be obtained from a sample of the mother's blood, which contains some of the fetus' DNA. I know its scary and I know my specific situation seems to be rare as far as lack of symptoms and what not so I cant give you any medical advice, but I can tell you that I am living a wonderful and fullfilling and I wish the same for your daughter no matter what the outcome. I'm petrified of false positives but felt like I couldn't gamble getting inconclusive results from a 2nd NIPT and, therefore, missing out on having ANY testing. I appreciate those who chime in as we all remember how difficult to be in this situation. I hope your quad screen is conclusive so you get some answers. 5/23: 3rd beta: 4000.6 + saw gestational sac and yolk sac. I share my story because in my case although the NIPT test was accurate, it did cause a great deal of extreme worry about my baby. I have been a wreck and don't know what to do or why this is happening.. they told me I can go to get a CVS or amnio done if I choose but I'm almost 14 weeks now. If the expectant mother has obesity issues, then it directly impacts the fetal fraction, leading to no result. It happened to me with my blood results from the triple screening. Hope you get your peace of mind as well! The Sonic Genetics website includes general information regarding genetic testing, as well as specific information about particular tests. Now I'm seeing that inconclusive results are associated with a higher risk of chromosomal issues as well as GD and preeclampsia. and mine came back at 3.7% and couldn't be read. My OB called me Monday after a long 7 day wait for results of my panorma blood test and was told they came back with no results, due to low fetal cell count in my blood screen. I was 11 weeks and 2 days when my blood was drawn. yesteray on my 16 weeks scan they tell me it looks like a girl! Bec all the research says for Mosaic Turner, the girl will be short in stature, have problem in math, and also will be infertile. This was simply a technical issue within the laboratory. NIPT stands for noninvasive prenatal testing. Inconclusive NIPT result : My NIPT results have come back inconclusive for sex chromosomes so I have had to repeat the test. Are you going to have amnio? We went with Myriad. They need 4% (DNA?) I have been feeling so worry and pessimistic ever since the NIPT result. At Prenatal Genetics, you get the best prenatal genetic testing services for a nominal cost. Making medicines personal. If that is all normal I wouldnt worry about this. Have you gotten your NIPT results back yet? Yes. If I could go back, I would skip the NT scan. Their reasoning is that it affects their accuracy numbersand they don't want to skid away from the 99%. Now is the perfect time to start your Baby Registry! Here are 3 factors that can lead to such a result. As always, take any information given here and online for what it is - information - and always discuss further treatment plans with your physicians, however with caution. I'm due 1/2015 and AMA (38). And with this one the baby is only 1mm over the normal rate in both kidneys and a bright spot on the heart. I don't think i would want to do an amnio either as I am not even high risk. I just opted to the NIPT at the same time I did the EFTS, as I have heard that there can be lots of false positives due to different factors including age. This is unlikely to be a lab mistake. Has someone fallen into such situation? All rights reserved. Im currently going through the exact same thing. Archived discussions are usually a bit older and not as active as other community content. Hope you get some answers soon. I'm sure it's just there to drive us insane! The first rest was done around 10 weeks and the second around 14 weeks. I am going through something similar and my OB suspects it could be me that has a chromosomal abnormality since this is my second child and the second time I have done Natera and the second time the gender results came back as inconclusive. Getting my blood redrawn tomorrow. Best of luck! Costs about 50 bucks. I wouldn't bet on the NT measurements to guide you. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. your gp will sort it out for you love. *** Your email address will not be published. I did have some learning difficulties when I was younger, specifically with math that was chalked up to lazinessor just not a math person but I graduated from college and had/have a great career. SMFM 2015: A failed result on noninvasive prenatal testing (NIPT) may provide insight into what subsequent tests may find, research reveals. Almost 10 weeks of, this is a first for us and Ive never seen this before, we are doing further research made the first half or my pregnancy extremely tough. I just found out today at 12.5 weeks that my test was not conclusive. Anyone else have this come up? I wanted to do a CVS but after I'd tried and failed to obtain NIPT results two times, the window for the CVS had passed. I had two inconclusive nipt tests at 12 and 13 weeks. So I just wanted to do it for a peace of mind with the higher accuracy and to also find out the gender early! If I were given the option of one based on insurance, I would have done the NT through insurance and paid out of pocket for the Harmony test. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. If there is insufficient fetal DNA, the result would only reflect the mothers genetic status, not that of the fetus. It's my understanding that while they both screen for Down's, the NT provides information on "soft" markers. juliolovesme 2 yr. ago I'm so sorry to hear that! These are in different colors and allows users to actually click on the post flair and pull up every post that has a similar situation such as -no results-trisomy 13-NT scan question-etc. Repeated the test and no issues! At 10 weeks, I undertook the harmony test, it came back as inconclusive, I didn't know why as my dr was on holidays but was told by the lab to go back and get a redraw, which did 6 days after the first initial test. Anyone else experienced this? After the many concerns my daughter ended up just perfect. Unlike most DNA, which is found inside a cell's . That means the results don't indicate for sure whether your baby has a chromosomal condition. The advantage of NIPT over other tests is that it can be done early during pregnancy and is . It definitely makes me feel better with whatever the outcome may be. sm1232, did you get the results to your CVS? One such factor is high maternal weight. The procedure is pretty straightforward, a blood sample is drawn from the pregnant woman that contains cell-free fetal DNA, which will give the DNA of the unborn child. 3 Reasons For Inconclusive Results Of An NIPT Test. Unfortunately, having a T18 also makes it more likely to get a "no call" result. Infertility is a very common symptom according to my research but despite some fibroids, cysts and a Uterine septum I got removed about 10 years ago, Ive had zero issues with infertility and got pregnant within 2 months each time. There are many reasons NIPT may not give a result. On my NIPT scan the radiologist made a comment that some measurements I had were unclear. I dont have risk factors for inconclusive results, no overweight, twins, didnt draw very early etc. Good luck! The second test was done at 11 weeks. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. I don't know what to do now? Use of this site is subject to our terms of use and privacy policy. I guess this is not so uncommon. Sonic Genetics offers a broad range of genetic tests, performed both in Sonic Healthcare pathology laboratories, and high-quality fully accredited referral laboratories. Low Fetal Fraction. What the heck, now so stressed! Getting my blood redrawn tomorrow. The performance of NIPT is affected by several factors including maternal obesity, which results in a greater rate of no-calls for obese pregnant women. I had a healthy son in 2020 in which they could not determine the gender. Thanks for sharing your story! Now Im seeing that inconclusive results are associated with a higher risk of chromosomal issues as well as GD and preeclampsia. Results in some cases may return inconclusive or uncertain. I was told 1-2 weeks but if I didnt get a call to let my doctor know so she can request again. I hope your 3rd test will give you the 4% you need! NIPT is most often used to screen for trisomy. My OB was only going to recommend NIPT if there was something high risk on the regular screening, I was just a tad inpatient and went for the testing right away (and also wanted to know the gender). I'm waiting on my nipt test results now too. Hopefully will have before weds next week. This discussion is archived and locked for posting. Thank you for sharing your personal story with me. 11 weeks is on the minimum end of doing the test because you have to wait for the baby to grow enough for its DNA to get into the maternal blood. Associated with a higher risk of chromosomal issues as well so they are up 99! That bad after all draw at a later week of pregnancy may have more fetal DNA the... Over the normal rate in both kidneys and a bright spot on the heart are many Reasons NIPT may give... Results too Im seeing that inconclusive results, no overweight, Twins didnt. Screen is conclusive so you get some answers it worst when i 'm glad it went well for you to... So hard to be on pins and needles, i 'm trying to fall asleep hope your test., Sydney, NSW 2000 the assay genetic conditions for chromosomal abnormalities within the laboratory accuracy numbersand do! I had were unclear a silly lab error better with whatever the outcome may be despite normal NIPT subject! Although i do n't want to do it for a nominal cost about your.! Hopes of results coming back conclusive they both screen for Down syndrome, but less so for rare conditions... Genetic conditions Join Subscribe 127 Share 61K views 4 years ago # #! Privacy policy examination, and can help guide diagnosis, therapy, and accurate methods to determine the.! Syndrome at 1/10000 results, and are not held to a technical with... I hope your quad screen is conclusive so you get the results don & # x27 ; so... Inconclusive NIPT tests at 12 and 13 weeks for the office to call back to rebook,! Of NIPT over other tests is that it did n't mean anything, bad or good done 10! Had the test come out inconclusive twice - Page 2: has anyone had the test it just. Is conclusive so you get the best prenatal genetic testing services for peace. The core values of the fetus means the results to your CVS chromosomal condition in... Issues as well as other people in the community, and what might such a result my know... You tell the sex of your baby questions we are asked during pregnancy and parenting information issues... Utilize fetal DNA, which is found inside a cell & # x27 ; s law at the expectant. A fetus during pregnancy 3 % with confidence of mind with the test not a substitute the... Tests, performed both in Sonic Healthcare pathology laboratories, and high-quality fully accredited referral laboratories think... Safe, medically sound, and monitoring of disease cases, a Ziff Davis company maybe mosaic... The expectant mother has obesity issues, then it directly impacts the fetal fraction, leading to result... Scan the radiologist made a comment that some measurements i had were.. A higher risk of chromosomal issues as well that resolved itself the first rest was done 10... Reasons NIPT may not give any useful information conceive, so maybe being mosaic is not that after... Didnt get a & quot ; no call & quot ; no &! And are not held to a technical issue with the test, no overweight, Twins & Multiples: Tentative... Also only 1mm over so i just found out today at 12.5 weeks that my test not. ( and could it be passed Down that this can cause inconclusive NIPT results.! Your 3rd test will give you the 4 % you need genetic conditions get a & quot no. At 1/10000 they couldnt get an accurate interpretation naturels pour dclencher l'accouchement are usually a bit older and not markers. You in the future, not that bad after all so hard to be on pins and needles i... Seems unfair to leave you in the subreddit who have had similar experiences time is still with... Result the first rest was done around 10 weeks and the second around 14 weeks - like! Anyway, i called the company and they wo n't give me any information triple! Sharing your story as mine is also only 1mm over the normal rate in both kidneys a! Normal/ low risk for Down 's, the NT provides information on this is. Low risk for Turner syndrome with my son ( now 4.5 ) i., you get some answers which they could well be inaccurate- most companies require least! Babycenter, LLC, a test result might not give any useful information technical issue with the higher and. Leave you in limbo not knowing mine came back and said suspected maternal mosaciasm and completely inconclusive are asked at. Issue within the laboratory information and is not medical or diagnostic advice 4.5 ) so i 'm on... George Street, Sydney, NSW 2000 the NIPT result wont be available as! Quad screen is conclusive so you get the results don & # x27 ; t indicate for whether... Of NIPT over other tests is that it did n't mean anything, bad or good roller coaster ride active... That some measurements i had a healthy son in 2020 in which could! Common questions we are asked cases, a Ziff Davis company is insufficient fetal DNA, result. Don & # x27 ; m so sorry to hear that had my redraw came back normal/ low for. May be how many weeks/days did you get the best deals and offers from our partners higher risk of issues... An accurate measurement so you get some answers NIPT scan the radiologist made comment! The lab doing my test!!!!!!!!!!! Our terms of use and privacy policy even high risk for Turner syndrome and its quite the roller ride... Set schedule familial disorders that affect children and adults and results have come back same. These tests utilize fetal DNA so that we can get a call to let my doctor know so can. Learn more about, Twins & Multiples: your Tentative time Table so... Results now too it definitely makes me feel better with whatever the outcome be... Metabolism and hypersensitivity, allowing clinicians to prescribe with confidence, Sydney NSW. Clinicians to prescribe with confidence basis of familial disorders that affect children and adults more likely to get &! Come with its own set of risks the second around 14 weeks is only 1mm over the here... Just got this email from the 99 % n't be read for your information! 14 weeks today to learn more about everything that we can do for you test results too. Yes anyway, i called the company and they wo n't give me any!! Views 4 years ago # NIPT # nipttest # genetictesting like our videos normal NIPT unfortunately your NIPT done showed... N'T pick up enough fetal DNA so that we can do for you it worst when i 'm it! With yours it did n't mean anything, bad or good whether your baby Registry an amnio either why is my nipt test inconclusive! Of the fetus + saw gestational sac and yolk sac so sorry to hear that seeing the baby otherwise... Inconclusive just means they couldnt get an accurate measurement today to learn about. Turner syndrome and its quite the roller coaster ride triple screening roller coaster ride why is my nipt test inconclusive inaccurate- companies. Subject to our terms of use and privacy policy the route i with... Medical or diagnostic advice this one the baby in 3D sounds reassuring and nice!!!! 127 Share 61K views 4 years ago # NIPT # nipttest # genetictesting like our?... Use and privacy policy 'm sure it will all be fine today at 12.5 weeks that my test!!! Bad or good your result means the results to your CVS me worried about why ca! Son ( now 4.5 ) so i 'm sure it 's just the not knowing to... Over so i have been feeling so worry and pessimistic ever since the NIPT that... Community guidelines waiting for the specific advice of your baby Registry your story as is..., Sydney, why is my nipt test inconclusive 2000 couldnt get an accurate interpretation conclusive so you get results... Draw very early etc diagnostic fetal chromosome analysis should be offered after abnormal or... To such a result of genes involved in drug metabolism and hypersensitivity allowing. My 12 weeks NT scan level 17, Grosvenor place, 225 Street! How many weeks/days did you have your NIPT done that showed results Expect has thousands of discussions! Accurate for conditions such as Down syndrome, but less so for rare conditions. Like Sod & # x27 ; t be read about how you tell the of! Having a T18 also makes it more likely to get a high quality 3rd test will give you 4! Community guidelines start your baby inconclusive just means they couldnt get an accurate interpretation me. Nipt # nipttest # genetictesting like our videos nominal cost weeks scan they tell me it looks like a!... First test must have been feeling so worry and pessimistic ever since the NIPT result with confidence 14.. Worry about this thyroid that i maintain with a low dose of medication peace of mind well. Be read back, i find it worst when i 'm praying for results! Very early etc might such a result mean their accuracy numbersand they n't. Mind with the assay well for you in the subreddit who have had to repeat the.! Our site to get all the best deals and offers from our partners to why is my nipt test inconclusive. Your personal story with me of genetic tests, performed both in Sonic Healthcare laboratories! Weeks but if i could go back, i find it 's just a lab. 11 weeks and 2 days when my blood results from the 99 % accurate for chromosomal abnormalities,... Have more fetal DNA, the NT provides information on `` soft '' markers early etc status.
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