BPA is fairly cheap to produce, as the synthesis benefits from a high atom economy and large amounts of both starting materials are available from the cumene process. Because of its extreme durability and strength, polycarbonate plastic is particularly useful for making component parts that need to be thin and light, but strong. Before sharing sensitive information, make sure you're on a federal government site. The FDAs National Center for Toxicological Research is continuing with an additional study: Rodent chronic toxicity study, which is currently underway. Bisphenol F (BPF) based epoxy resins are more flexible than that of BPA-based epoxies. In July, 2013, FDA took this action in response to a food additive petition filed by Congressman Edward Markey [10] of Massachusetts. [92] It is primarily a river pollutant,[93] but has also been observed in the marine environment,[94] in soils,[95] and lower levels can also be detected in air. You can also browse global suppliers,vendor,prices,Price,manufacturers of Bisphenol A epoxy resin(). . The original approvals for BPA were issued under FDAs food additive regulations and date from the 1960s. Scientific Peer-Review of the Draft Assessment of Bisphenol A for Use in Food Contact Applications, 31 October 2008. It is prepared by the reaction of two equivalents of phenol with one equivalent of acetone. Excessive amounts of bisphenol A generate linear high molecular compounds with hydroxyl-, etherand epoxy-terminated groups. The oligomers may vary in molecular weight from 340 and higher. Sign in to download full-size image fatty acid dimers, +undefined-86-13650506873 +undefined-86-13650506873. Free of claims are used to indicate that a product does not contain a certain material, such as BPA, but they can sometimes be misleading. These may be incorporated at low levels in vinyl ester resins to change their physical properties[45] and see common use in dental composites and sealants.[46][47]. Polymerisation is achieved by a reaction with phosgene, conducted under biphasic conditions; the hydrochloric acid is scavenged with aqueous base. By varying the relationship between bisphenol A and epichlorohydrin, various molecular weights are obtained for the completed epoxy resin. The .gov means its official.Federal government websites often end in .gov or .mil. FDAs Studies. It belongs to the phenol class of aromatic organic compounds. An amendment of the food additive regulations based on abandonment is not based on safety, but is based on the fact that the regulatory authorization is no longer necessary for the specific use of the food additive because that use has been permanently and completely abandoned. Bisphenol A diglycidyl ether (DGEBA) is a pale yellow liquid epoxy compound formed by the polycondensation of epichlorohydrin (ECH) and bisphenol A (BPA). CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME:WEST SYSTEM 105 Epoxy Resin Find out about the exciting discoveries being made by NIEHS and NIEHS-supported researchers that are helping to improve health and save lives. The FDA review has not found any information in the evaluated studies to prompt a revision of FDAs safety assessment of BPA in food packaging at this time. 80-05-7 Bisphenol a with Wholesale Price Min. [70][71] The body first converts it into more water-soluble compounds via glucuronidation or sulfation, which are then removed from the body through the urine. This petition demonstrated, from publicly available information and information collected from industry sources, that the use of BPA-based epoxy resins as coatings in packaging for infant formula had been abandoned. Toxicol Appl Pharmacol. [28] BPA was never used as a drug. Many BPA-containing materials are non-obvious but commonly encountered,[17] and include coatings for the inside of food cans,[18] clothing designs,[19] shop receipts,[20] and dental fillings. [98], In all cases, wastewater treatment can be highly effective at removing BPA, giving reductions of 9198%. EC number: 500-130-2 Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats. If youve ever read a news article or blog post about chemicals, you may have heard the oft-cited claim that there are 84,000 chemicals in commerce but only 200 of these have been tested for safety. [35][34], BPA has a fairly high melting point but can be easily dissolved in a broad range of organic solvents including toluene, ethanol and ethyl acetate. Epoxy resin is a polymer with the molecular formula (C11H12O3)n, which is a general term for a class of polymers containing more than two epoxy groups in the molecule. Other Details: - Bisphenol resin is extensively used with consumer products such as applying coatings inside of food and beverage cans as this leave no bad effects or any risk of hazard to human health. Reports indicate that it is a minor skin irritant as well, although less so than phenol. Toxicol Lett. Regardless, due to the scientific uncertainty, many jurisdictions have taken steps to reduce exposure on a precautionary basis. [4] http://www.regulations.gov/document/FDA-2010-N-0100-0006. Bisphenol A (BPA) is a chemical building block that is used primarily to make polycarbonate plastics. Epoxy resin | C21H25ClO5 | CID 169944 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. [66][67][68] The primary source of human exposure is via food, as epoxy and PVC are used to line the inside of food cans to prevent corrosion of the metal by acidic foodstuffs. It is important to note that scientific experts at FDA, and other regulatory bodies, review the full weight of the scientific evidence when making decisions about safety. 1675-54-3 Chemical Name: BISPHENOL A DIGLYCIDYL ETHER RESIN CBNumber: CB3749115 Molecular Formula: C21H24O4 Molecular Weight: 340.41 MDL Number: MFCD00080480 MOL File: 1675-54-3.mol MSDS File: SDS Modify Date: 2022-12-30 16:20:48 Request For Quotation BISPHENOL A DIGLYCIDYL ETHER RESIN Properties SAFETY The performance represented by each part of the Bisphenol A-type epoxy resin is shown here: Araldite? BPA's largest single application is as a co-monomer in the production of polycarbonates, which accounts for 6570% of all BPA production. It is found in various products including shatterproof windows, eyewear, water bottles, and epoxy resins that coat some metal food cans, bottle tops, and water supply pipes. [8], Usually, the addition of acetone takes place at the para position on both phenols, however minor amounts of the ortho-para (up to 3%) and ortho-ortho isomers are also produced, along with several other minor byproducts. Download or play NIEHS Health Chat's with a wide range of experts and topics. Epub 2014 Feb 4. b) Delclos KB, Camacho L, Lewis SM, Vanlandingham MM, Latendresse JR, Olson GR, Davis KJ, Patton RE, Gamboa da Costa G, Woodling KA, Bryant MS, Chidambaram M, Trbojevich R, Juliar BE, Felton RP, Thorn BT. Chemical Identity. Food Additives & Petitions. Bisphenol A is the chemical product of combining one acetone unit with two phenol groups. Polycarbonate plastic also is used to make housings for electronic products such as cell phones and laptops, as well as optical discs such as CDs and DVDs. To improve the compatibility between flame retardant and epoxy resin (EP) matrix, amino phenyl copper phosphate-9, 10-dihydro-9-oxygen-10-phospha-phenanthrene-10-oxide (CuPPA-DOPO) is synthesized through surface grafting, which is blended with EP matrix to prepare EP/CuPPA-DOPO composites. 2011 Nov;124(1):149-60. k) He Z, Paule MG, Ferguson SA. tions of epoxy resins can be preset by the chemical structure of the resin and hardener, as well as by the . [73] Concern is mostly related to its estrogen-like activity, although it can interact with other receptor systems as an endocrine-disrupting chemical. To address these questions the National Toxicology Program, partnering with FDAs National Center for Toxicological Research is carrying out in-depth studies to answer key questions and clarify uncertainties about BPA. Background. It is the lowest molecular weight epoxy resins, and also used as the packaging material for coatings, adhesives, insulating paints, semiconductors, and integrated circuits and other electronic components. The internal rotation function of the ether bond increases the flexibility of the molecule, and the hydroxyl group enhances the chemical reactivity and the bonding ability, the epoxy group cross-links molecules into a three-dimensional network structure by reacting with a curing agent. [87][88], BPA exhibits very low acute toxicity as indicated by its LD50 of 4g/kg (mouse). Table 1, Table 2 present the . The ACC petition demonstrated, from publicly available information and information collected from industry sources, that the use of polycarbonate resins in baby bottles and sippy cups had been abandoned. 2011 Nov 15;257(1):122-36. i) Doerge DR, Vanlandingham M, Twaddle NC, Delclos KB. We provide Bisphenol A epoxy resin safety data sheet view and download for free at Echemi.com. Chemical Name: Hydrogenated Bisphenol A Epoxy Resin CAS No. It is a colourless solid which is soluble in most common organic solvents, but has very poor solubility in water. PubChem CID 24754; . The reaction process is as follows: Some of this is further reacted with methacrylic acid to form bis-GMA, which is used to make vinyl ester resins. What Does U.S. Government Research Tell Us About BPA? [7], BPA has been found to interact with a diverse range of hormone receptors, in both humans and animals. [90] This may be the mechanism by which BPA acts as a xenoestrogen. resins are bisphenol A diglycidyl ether (DGEBA) and epoxy phenol Using the data and design from the rodent subchronic study, the National Toxicology Program/Food and Drug Administration (NTP/FDA) is conducting a long-term toxicity study of BPA in rodents to assess a variety of endpoints, including novel endpoints where questions have been raised. Because of these attributes, polycarbonate is used in a wide variety of common products including digital media (e.g., CDs, DVDs), electrical and electronic equipment, automobiles, sports safety equipment, reusable food and drink containers, and many other products. Bisphenol A-type epoxy resin is bisphenol A and epichlorohydrin under the action of sodium hydroxide condensation derived. This group may lie within the body of the molecule but is usually terminal. [37] Crystals form in the monoclinic space group P 21/n (where n indicates the glide plane); within this individual molecules of BPA are arraigned with a 91.5 torsion angle between the phenol rings. At that time, another synthetic compound, diethylstilbestrol, was determined to be more powerful than estrogen itself, so bisphenol A was not used as a synthetic estrogen. 2010 Oct 1;248(1):1-11. h) Fisher JW, Twaddle NC, Vanlandingham M, Doerge DR. Pharmacokinetic modeling: prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans. BPA can both mimic the action of estrogen and antagonise estrogen, indicating that it is a selective estrogen receptor modulator (SERM) or partial agonist of the ER. Recalls, Market Withdrawals and Safety Alerts, Substances Added to Food (formerly EAFUS), Bisphenol A (BPA): Use in Food Contact Application, Summary of FDAs Current Perspective on BPA in Food Contact Applications, Overview of BPA Usage in Food Contact Applications, Increasing Our Understanding about the Biology and Metabolism of BPA, Food Additive Regulations Amended to No Longer Provide for the Use of BPA-Based Materials in Baby Bottles, Sippy Cups, and Infant Formula Packaging, based on its most recent safety assessment, Final report for the review of literature and data on BPA, 2014 Updated Review of Literature and Data on Bisphenol A, 2012 Updated Review of Literature and Data on Bisphenol A, Updated Review of the Low-Dose Literature (Data) on Bisphenol A and Response to Charge Questions Regarding the Risk Assessment on Bisphenol, Draft Assessment of Bisphenol A for Use in Food Contact Applications, Scientific Peer-Review of the Draft Assessment of Bisphenol A for Use in Food Contact Applications. It is prepared by the reaction of two equivalents of phenol with one equivalent of acetone. Uses of all substances that migrate from packaging into food,. mixing process is what I used. 250/ Ton Get Latest Price. Bisphenol A is an organic synthetic compound used in formulating plastics and epoxy resin. The performance of specialized collections of bisphenol A epoxy resin system components in the evaluation of workers in an occupational health . 2010 Dec 15;199(3):372-6. j) Ferguson SA, Law CD Jr, Abshire JS. 12 oz. Alternatively, bisphenol A (BPA) definition is that it is a synthetically obtained colourless crystalline organic compound that occurs in the solid phase belonging to the diphenylmethane group and is soluble in organic solvents but poorly dissolves in water (0.344 % wt. [90] Different expression of ERR- in different parts of the body may account for variations in bisphenolA effects. 2013 Feb 15;267(1):41-8. m) Twaddle NC, Churchwell MI, Vanlandingham M, Doerge DR. Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry. Brand Names: Not applicable . 506 epoxy resin has been used as an embedding medium for microscopy. .mw-parser-output .ib-chembox{border-collapse:collapse;text-align:left}.mw-parser-output .ib-chembox td,.mw-parser-output .ib-chembox th{border:1px solid #a2a9b1;width:40%}.mw-parser-output .ib-chembox td+td{width:60%}, Bisphenol A (BPA) is a chemical compound primarily used in the manufacturing of various plastics. Toxicol Appl Pharmacol. An official website of the United States government. Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics. Polycarbonate drinks containers are also a source of exposure, although most disposable drinks bottles are actually made of PET, which contains no BPA. 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